Alexander MacDonald
Chief Technology Officer at Innolytics
Education
Ph.D. in Analytical Chemistry, University of Iowa
M.S. in Chemistry, Northeastern University
B.S. in Chemistry, University of Iowa
Expertise
- Pharmaceutical Sciences
- Analytical Chemistry
- FDA Consultation
- AOAC Methodology
- Veterinary Drug Development
About
Dr. Alexander MacDonald is a distinguished figure in the fields of pharmaceutical sciences and veterinary drug development. With a career spanning several decades, his expertise and contributions have left an indelible mark on these industries. He currently resides in North Caldwell, New Jersey, where he continues to make significant strides in these fields.
Education
Dr. MacDonald's academic journey began at the University of Iowa, where he pursued Analytical Chemistry. Subsequently, he earned a Master of Science (M.S.) in Chemistry from Northeastern University in Boston, Massachusetts. His academic pursuits culminated in a Ph.D. in 1963, demonstrating his dedication to advancing scientific knowledge.
Professional Experience
Dr. MacDonald's professional journey has been nothing short of remarkable. Since January 2003, he has served as the Chief Technology Officer at Innolytics, LLC. In this role, he has been at the forefront of developing Nicarbazin as a hatch control agent for resident Canada geese. His work involves formulation development, blood analyses, and biological evaluation for EPA registration, as well as efficacy protocols for Nicarbazin development for Canada geese, pigeons, and ducks.
Since January 1995, Dr. MacDonald has also held the position of Scientific Director at Pharma Science, Inc. In this capacity, he has provided invaluable consulting services to the pharmaceutical industry. His areas of expertise include compound characterizations, method development, bioavailability studies, GMP and GLP compliance, residue food safety evaluations, and much more.
Additional Experience
Before his current roles, Dr. MacDonald served as a Research Leader, Manager, Research Director, and Research Fellow at various departments of Hoffmann-LaRoche, Inc. in Nutley, New Jersey. His responsibilities encompassed compound characterization, analytical method development, method validation, and documentation for CMC segments of INDA/NDA. He also contributed to pharmaceutical product method validation, stability proofing, and documentation for CMC segments of INDA/NDA.
Throughout his career, Dr. MacDonald has played a pivotal role in developing new analytical methods for drug residue and metabolite determination in veterinary drugs and agricultural chemicals. His work has included environmental impact assessments, radiolabeled studies, and bioavailability assessments.
Publications and Recognition
Dr. MacDonald's impact is further evident in his extensive publications and contributions, with a focus on Nicarbazin. His research and findings have significantly advanced our understanding of this critical area. Notable publications include:
"OvoControl P 0.5% (nicarbazin) Population Dynamics in Pigeons." This work was presented as a poster as part of the 6th International IPM Symposium in Portland, Oregon, in March 2009.
"Quantification of plasma and egg 4,4’dintrocarbanilide (DNC) residues for the efficient development of a nicarbazin-based contraceptive for pest waterfowl." This publication appeared in Pest Management Science, with an online publication date in 2001.
"Determination and Identification of Nicarbazin in Chicken Tissues." This work contributed to the AOAC Official Method 2013.07, which utilizes Liquid Chromatography with Tandem Mass Spectrometry. This method was finalized in 2021.
"The Political and Social Barriers for Contraception in Pest Birds: A Case Study of OvoControl (nicarbazin)." This publication can be found in the Journal of Zoo and Wildlife Medicine, specifically in volume 44(4S), with pages S132-S134, published in 2013.
"Nicarbazin Residue in Chicken Tissue: The Effect of Litter Recycle in Three Studies." Proceedings of EuroResidue IV, with a publication date of 8-10 May 2000, held in Veldhoven, The Netherlands.
Dr. Alexander MacDonald's illustrious career and unwavering commitment to advancing pharmaceutical sciences and veterinary drug development make him a respected and influential figure in the industry. His dedication to ensuring safety and efficacy in these critical areas, along with his valuable research on Nicarbazin, continues to leave a lasting impact on the field.
